The research has a direct application in viticulture and wine production in the Republic of Croatia. It is planned to examine the potential of changing the moment of application of ampelotechnical interventions with the aim of adapting viticulture and wine production to climate change through the implementation of the project at representative locations where vines are grown. The application of optimal fertilization and pruning should significantly affect the yield and the qualitative composition of grapes, must and wine. Also, growers and winemakers should be provided with a reduction and optimization of production costs. Through the overall processing and analysis of all the obtained results, it will be possible to give producers a recommendation on how to adapt multi-year production to climate change in the research area without additional investments. All together, it should be possible to increase the competitiveness of producers, both in the domestic and foreign markets. In addition to the above, it is certainly worth noting that the results of this project will be presented through promotional activities such as presentations at professional conferences and scientific symposia, conferences and workshops and publication in relevant professional and scientific journals. We also believe that it will have a significant impact on the protection of animal and plant health and that it will indicate the possibility of exploiting by-products.