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Alternatives to Veterinary Antimicrobials
Alternatives to Veterinary Antimicrobials

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Ongoing | 2020 - 2024 Austria, Belgium, Denmark, France, Germany, Netherlands, Spain, United Kingdom
Ongoing | 2020 - 2024 Austria, Belgium, Denmark, France, Germany, Netherlands, Spain, United Kingdom
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Objectives

AVANT is a multi-actor inter-sectorial project aimed at developing alternatives to antimicrobials for the management of bacterial infections in pigs, especially diarrhoea during the weaning period, as the major indication for antimicrobial use in livestock in Europe. During pre-clinical studies, efficacy, toxicity, and mode of action of these interventions is tested, and their dosage and formulation optimized. The results and a survey for veterinarian-, farmer- and consumers perception of antimicrobial alternatives, will be used together with legal and economic considerations to select three interventions for large-scale farm trials, assessing clinical efficacy and impact on antimicrobial use.

Objectives

AVANT is a multi-actor inter-sectorial project aimed at developing alternatives to antimicrobials for the management of bacterial infections in pigs, especially diarrhoea during the weaning period, as the major indication for antimicrobial use in livestock in Europe. During pre-clinical studies, efficacy, toxicity, and mode of action of these interventions is tested, and their dosage and formulation optimized. The results and a survey for veterinarian-, farmer- and consumers perception of antimicrobial alternatives, will be used together with legal and economic considerations to select three interventions for large-scale farm trials, assessing clinical efficacy and impact on antimicrobial use.

Activities

The AVANT portfolio comprises a variety of alternatives for treatment or prevention of diarrhoea and/or respiratory infections, namely:



• Gut-stabilizing interventions based on a symbiotic (pre- and probiotic) product and faecal microbiota transplantation

• Novel veterinary medicinal products containing bacteriophages and polymers for targeted treatment of enterotoxigenic E. coli infections

• Immuno-stimulating injectable and feed additive products

• Alternative feeding strategies targeting sows and piglets



All steps are supported by regulatory advice for quick market entry post-project. Generated and existing data on antimicrobial use, pig demographics and projected consumption of pork, will be used in mathematical modelling to estimate the reduction in antimicrobial use that could be achieved by 2030, if the AVANT alternatives were widely adopted in pig production.

Additional information

AVANT has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862829.

Project details
Main funding source
Horizon 2020 (EU Research and Innovation Programme)
Project acronym
AVANT
Agricultural sectors
  • Livestock (generic)
  • Pigs

€ € 6 537 033,75

Total budget

Total contributions including EU funding.

€ € 5 999 905,02

EU contribution

Any type of EU funding.

Project keyword

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Contacts

Stefan Weiss

Project coordinator

  • University of Copenhagen

    Project coordinator

    Luca Guardabassi lg@sund.ku.dk 06802312182 Department of Veterinary and Animal Sciences, Stigbøjlen 4, 1870 Frederiksberg C, Denmark Researcher

Project partners

  • Biomin

    Project partner

    Ryan Hines ryan.hines@biomin.net +43 2782 803 11245 BIOMIN Holding GmbH Erber Campus 1, 3131 Getzersdorf, Austria Industry

  • Cooperl

    Project partner

    Arnaud Buchet arnaud.buchet@cooperl.com Cooperl, 7 rue de la jeannaie - Maroué, 22, 400 Lamballe, France Industry

  • Easy-Agricare

    Project partner

    Lars Sørensen lars@easy-agricare.dk +45 23 35 03 83 Easy-AgriCare A/S, Østermøllevej 32, 7900 Nykøbing Mors, Denmark SME

  • Federation of Veterinarians of Europe

    Project partner

    Jan Vaarten jan@fve.org +32 (0) 2 533 70 20 Federation of Veterinarians of Europe (FVE), Avenue de Tervueren 12, 1040 Brussels, Belgium Other

  • Klifovet

    Project partner

    Rike Brunner Rike.Brunner@klifovet.com +49 (0) 89 5800820 KLIFOVET AG, Geyerspergerstr. 27, 80689 München, Germany SME

  • Ovejero Laboratories

    Project partner

    Gabriel Moyano gabriel.moyano@labovejero.es +34 902 235 700 LABORATORIOS OVEJERO SA, Crta. León-Vilecha 30, 24192 León, Spain Industry

  • Royal Veterinary College

    Project partner

    Liam Good lgood@rvc.ac.uk The Royal Veterinary College, Royal College Street, London NW1, United Kingdom Researcher

  • RTDS Group

    Project partner

    Stephen Webb webb@rtds-group.com +43 (0) 1-3231000 Lerchengasse 25 / 2-3, 1190 Vienna, Austria SME

  • Schothorst Feed Research

    Project partner

    Francesc Molist Fmolist@schothorst.nl +31320229626 SFR, P.O. Box 533, 8200 AM Lelystad, The Netherlands SME

  • Danish Agriculture & Food Council F.m.b.A. SEGES

    Project partner

    Poul Bækbo pb@seges.dk +45 3339 4920 SEGES Agro Food Park 15, 8200 Aarhus N, Denmark Industry

  • Swiss Federal Institute of Technology, Zurich

    Project partner

    Thomas Van Boeckel thomas.vanboeckel@env.ethz.ch +41 44 632 32 19 ETH, Sonneggstrasse 33, 8092 Zurich, Switzerland Researcher

  • Universidad Complutense de Madrid

    Project partner

    Bruno Gonzalez-Zorn bgzorn@ucm.es +91 394 3707 Universidad Complutense, Avda. Puerta de Hierro s/n, Ciudad Universitaria, 28040 Madrid, Spain Researcher

  • Wageningen Research

    Project partner

    Alfons Jansman alfons.jansman@wur.nl +31317480717 Wageningen Livestock Research, Animal Nutrition, PO Box 338, 6700 AH, Wageningen, The Netherlands